The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
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Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7Defective T cell receptor-mediated signal transduction in memory CD4 T lymphocytes exposed to superantigen or anti-T cell receptor antibodiesGlycosylated extracellular domains of membrane immunoglobulin M contribute to its association with mb-1/B29 gene products and the B cell receptor complexDifferential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphataseCTLA-4 up-regulation plays a role in tolerance mediated by CD45.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentQualitative differences between naïve and memory T cells.Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy.CD45: all is not yet crystal clear.9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.Anti-lymphocyte autoantibodies in systemic lupus erythematosus.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.Mediation of T-cell activation by actin meshworksCD45-associated protein promotes the response of primary CD4 T cells to low-potency T-cell receptor (TCR) stimulation and facilitates CD45 association with CD3/TCR and lck.A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells.Low and nontoxic levels of ionic mercury interfere with the regulation of cell growth in the WEHI-231 B-cell lymphoma.Expression of the sialosyl-Tn epitope on CD45 derived from activated peripheral blood T cells.Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis of Lichen Planus and Lichenoid Mucositis.Phosphorylation of extracellular domains of T-lymphocyte surface proteins. Constitutive serine and threonine phosphorylation of the T cell antigen receptor ectodomains.Identification of a human CD4-CDR3-like surface involved in CD4+ T cell function.The role of CD45 and CD45-associated molecules in T cell activation.Combinations of CD45 isoforms are crucial for immune function and diseaseLFA-1 is a key determinant for preferential infection of memory CD4+ T cells by human immunodeficiency virus type 1.Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.Extracellular domain splice variants of a transforming protein tyrosine phosphatase alpha mutant differentially activate Src-kinase dependent focus formation.Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.The role of intron sequences in high level expression from CD45 cDNA constructs.Non-responsiveness of antigen-experienced CD4 T cells reflects more stringent co-stimulatory requirements.Structural and functional analysis of the human CD45 gene (PTPRC) upstream region: evidence for a functional promoter within the first intron of the gene.Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules.Defective IL2 gene expression in newborn is accompanied with impaired tyrosine-phosphorylation in T cells.Interactions of CD45-associated Protein with the Antigen Receptor Signaling Machinery in T-lymphocytes
P2860
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P2860
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
The extracellular domain of CD ...... antigen-specific stimulation.
@en
type
label
The extracellular domain of CD ...... antigen-specific stimulation.
@en
prefLabel
The extracellular domain of CD ...... antigen-specific stimulation.
@en
P2093
P2860
P356
P1476
The extracellular domain of CD ...... antigen-specific stimulation.
@en
P2093
P2860
P304
P356
10.1084/JEM.183.1.249
P407
P577
1996-01-01T00:00:00Z