The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
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CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cellsCD28 and CTLA-4 have opposing effects on the response of T cells to stimulationThe Multifaceted Roles of PI3Kγ in Hypertension, Vascular Biology, and InflammationUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingTwo distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase associationGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionPIP3 pathway in regulatory T cells and autoimmunityThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulationMiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.The role of CTLA-4 in the regulation of T cell immune responses.CD28/CTLA-4 and CD80/CD86 families: signaling and function.Regulation of integrin function by T cell activation: points of convergence and divergence.Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment.Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptorAn enigmatic tail of CD28 signaling.On guard--activating NK cell receptors.p85beta phosphoinositide 3-kinase regulates CD28 coreceptor functionActivated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1.Dynamic motile T cells highly respond to the T cell stimulation via PI3K-Akt and NF-κB pathways.Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.Genetic analysis of integrin activation in T lymphocytes.Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cellsPhosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.Itk negatively regulates induction of T cell proliferation by CD28 costimulation.Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes.RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationUnmasking the immune recognition of prostate cancer with CTLA4 blockade.Confusing signals: recent progress in CTLA-4 biologyAkt is a neutral amplifier for Th cell differentiation.Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma.CD28 Costimulation: From Mechanism to Therapy.
P2860
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P2860
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The cytoplasmic domain of CD28 ...... hosphatidylinositol 3'-kinase.
@en
type
label
The cytoplasmic domain of CD28 ...... hosphatidylinositol 3'-kinase.
@en
prefLabel
The cytoplasmic domain of CD28 ...... hosphatidylinositol 3'-kinase.
@en
P2093
P2860
P356
P1476
The cytoplasmic domain of CD28 ...... hosphatidylinositol 3'-kinase.
@en
P2093
P2860
P304
P356
10.1128/MCB.14.5.3392
P407
P577
1994-05-01T00:00:00Z