DNA-PK: at the cross-roads of biochemistry and genetics.
about
Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinaseReplication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexesThe C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunitDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexbeta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocationUp-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinomaHomologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cellsDNA replication but not nucleotide excision repair is required for UVC-induced replication protein A phosphorylation in mammalian cellsThymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cellsATM: a mediator of multiple responses to genotoxic stress.p53 regulation by post-translational modification and nuclear retention in response to diverse stresses.Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoiningInterstrand cross-links induce DNA synthesis in damaged and undamaged plasmids in mammalian cell extracts.The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinaseActivation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres.Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiationXR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.Molecular targets in cellular response to ionizing radiation and implications in space radiation protection.Mechanism of radiosensitization by hyperthermia (> or = 43 degrees C) as derived from studies with DNA repair defective mutant cell lines.Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response.Short telomeres result in organismal hypersensitivity to ionizing radiation in mammalsA human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency.KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.The involvement of DNA-damage and -repair defects in neurological dysfunctionThe fine line between lifespan extension and shortening in response to caloric restriction.Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity.The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity.Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.High-level transgene expression by homologous recombination-mediated gene transfer.UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells.DNA-PK is essential only for coding joint formation in V(D)J recombinationRepair of a minimal DNA double-strand break by NHEJ requires DNA-PKcs and is controlled by the ATM/ATR checkpoint.Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.Reconstitution of active telomerase in primary human foreskin fibroblasts: effects on proliferative characteristics and response to ionizing radiation.DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts.Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells.Recombination between homologous chromosomes does not play a dominant role in the formation of radiation-induced chromosomal aberrations.
P2860
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P2860
DNA-PK: at the cross-roads of biochemistry and genetics.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
DNA-PK: at the cross-roads of biochemistry and genetics.
@en
type
label
DNA-PK: at the cross-roads of biochemistry and genetics.
@en
prefLabel
DNA-PK: at the cross-roads of biochemistry and genetics.
@en
P1433
P1476
DNA-PK: at the cross-roads of biochemistry and genetics.
@en
P2093
P356
10.1016/S0921-8777(97)00009-8
P407
P577
1997-06-01T00:00:00Z