The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.
about
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesIn vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger proteinThe solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PMLPMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivoPML, a growth suppressor disrupted in acute promyelocytic leukemiaThe promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma proteinBtg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylationHigh throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samplesModulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signalingDual effect of oxidative stress on leukemia cancer induction and treatmentBleeding related to disturbed fibrinolysisThe coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasomePRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cellsZinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for bindingCytoplasmic PML function in TGF-beta signallingIdentification of three major sentrinization sites in PMLThe serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cellsPIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemiaDNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemiaArsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemiaRetinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemiaRecruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.Translocations, cancer and the puzzle of specificity.Acute promyelocytic leukemia with the translocation t(15;17)(q22;q21) associated with t(1;2)(q42~43;q11.2~12): a case reportNeutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party.Curing all patients with acute promyelocytic leukemia: are we there yet?Acute promyelocytic leukemia: from treatment to genetics and back.Advances in cancer cytogenetics.Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation.CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy.PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse modelThe DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.Transcription therapy for acute promyelocytic leukaemia.ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells.Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.
P2860
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P2860
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The acute promyelocytic leukem ...... al of myeloid precursor cells.
@en
type
label
The acute promyelocytic leukem ...... al of myeloid precursor cells.
@en
prefLabel
The acute promyelocytic leukem ...... al of myeloid precursor cells.
@en
P2093
P1433
P1476
The acute promyelocytic leukem ...... al of myeloid precursor cells.
@en
P2093
Ferrucci PF
Grignani F
Mencarelli A
Nicoletti I
P304
P356
10.1016/0092-8674(93)80044-F
P407
P50
P577
1993-08-01T00:00:00Z