Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.
about
Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteinsPIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteinsPIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchorSpecificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidaseGlycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.Metabolism of exogenous sn-1-alkyl-sn-2-lyso-glucosaminyl-phosphatidylinositol in HeLa D cells: accumulation of glucosaminyl(acyl)phosphatidylinositol in a metabolically inert compartmentGlycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum.Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness.Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis.Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositolsIdentification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae.Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation.Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.COOH-terminal processing of nascent polypeptides by the glycosylphosphatidylinositol transamidase in the presence of hydrazine is governed by the same parameters as glycosylphosphatidylinositol addition.The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.Glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae: absence of ceramides from complete precursor glycolipidsA defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins.Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin.Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol anchor.Biosynthesis of glycosylphosphatidylinositol membrane anchors.The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.Isolation and characterization of a Chinese hamster ovary (CHO) mutant defective in the second step of glycosylphosphatidylinositol biosynthesis.Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer.Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analoguesSubstrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells.Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.Accumulation of glucosaminyl(acyl)phosphatidylinositol in an S3 HeLa subline expressing normal dolicholphosphomannose synthase activity.The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol.Inositol acylation of glycosylphosphatidylinositols in the pathogenic fungus Cryptococcus neoformans and the model yeast Saccharomyces cerevisiae.
P2860
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P2860
Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Characterization of putative g ...... zation of phosphoethanolamine.
@en
type
label
Characterization of putative g ...... zation of phosphoethanolamine.
@en
prefLabel
Characterization of putative g ...... zation of phosphoethanolamine.
@en
P2093
P1476
Characterization of putative g ...... ization of phosphoethanolamine
@en
P2093
Rosenberry TL
Sevlever D
P304
16968-16974
P407
P577
1992-08-01T00:00:00Z