The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level.
about
N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adductsO(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problemsReplication past O(6)-methylguanine by yeast and human DNA polymerase eta.Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119WNEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine.Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy.Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks.DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses.DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapyRepair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomideChloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma.Effect of spermine synthase on the sensitivity of cells to anti-tumour agents.Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments.pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.
P2860
Q24805889-E2119571-16BA-4A18-B901-94175FAF5761Q26853112-6BB44033-0D25-433E-A61F-48DC407A5479Q27930712-1C0DE286-E1A6-4CA1-A78C-7D11237C3AE2Q30454407-CF872195-C9D3-400E-A843-7DEEC0CEEAECQ33662290-3B22E8A8-F1D9-4E39-BA2C-DDC8E68C53A1Q33905518-5CEE245C-25F2-4261-A367-D5D9E485A910Q33924789-EEE74210-C9DB-4E45-9C5B-24E6224EB8FEQ34065933-E2CAA328-8AD9-478C-8164-F5349686EEACQ34132691-6454F874-5C0B-4C01-933B-945E587E61B1Q34178990-2C0B03F9-3E40-4CDD-B2D7-8C879EB28661Q35130367-2FB0DD04-6784-44B2-A89F-9455E955DD21Q36002324-57D67B53-F859-4C9A-AD40-971BC1F1B735Q36012002-DD4CEE9E-13D2-4A7C-A78F-171AFB49A066Q36449769-C1FD4293-DD08-4241-A18F-281541D712D9Q36674877-7B96598D-4408-4C16-8E7D-D6835B192103Q37412218-FBA904B2-7A48-4853-A7B4-4132E8C90496Q37861732-2D76BD31-D4E9-4CE5-9808-E7D14398BCB0Q38261426-6E3F4EF3-90F9-4E3D-AC50-E97C0462EC82Q39060025-3BE86878-402F-4931-9DC3-D485A00B7642Q39354541-8EB3BD24-41AE-4963-A8A5-1D8BAA66C17BQ41829551-B2657DB2-BC21-46EF-BB38-4C63E596C18AQ41856771-A6A40C87-FBA4-40C8-929A-856646A999B4Q41879640-2DD79B15-F2AE-4615-AD4A-A9CCEB6E36D3Q46346689-F6EA4F27-3054-4F0C-A95F-B243C055BBF7Q48256976-0376A59F-02DE-4E1B-A58B-655071A88A9B
P2860
The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The chloroethylnitrosoureas: s ...... herapy at the molecular level.
@en
type
label
The chloroethylnitrosoureas: s ...... herapy at the molecular level.
@en
prefLabel
The chloroethylnitrosoureas: s ...... herapy at the molecular level.
@en
P2860
P1433
P1476
The chloroethylnitrosoureas: s ...... herapy at the molecular level.
@en
P2093
P2860
P304
P356
10.3109/07357909709047601
P577
1997-01-01T00:00:00Z