Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.
about
Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinasesA motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.PKC-Theta in Regulatory and Effector T-cell FunctionsThe Novel PKCθ from Benchtop to ClinicProtein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responsesRegulated movement of CD4 in and out of the immunological synapseSpatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.Structural basis of protein kinase C isoform functionT cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.Protein kinase C-theta (PKCtheta): it's all about location, location, location.The PKC gene module: molecular biosystematics to resolve its T cell functions.HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication.An active kinase domain is required for retention of PKCθ at the T cell immunological synapse.Emerging and diverse roles of protein kinase C in immune cell signalling.Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.Regulation of PKC-θ function by phosphorylation in T cell receptor signaling.Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators.Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cellsPKCtheta signals activation versus tolerance in vivoA phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.In and out of the bull's eye: protein kinase Cs in the immunological synapse.Protein kinase C theta (PKCtheta): a key player in T cell life and deathTargeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationRegulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.Protein kinase C-theta in platelet activation.PKCθ-regulated signalling in health and disease.Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors.Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation.The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells.Involvement of distinct PKC gene products in T cell functionsBinding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase.The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation.Mutational analysis of stress-responsive peanut dual specificity protein kinase. Identification of tyrosine residues involved in regulation of protein kinase activity.
P2860
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P2860
Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Regulation of protein kinase C ...... ated tyrosine phosphorylation.
@en
type
label
Regulation of protein kinase C ...... ated tyrosine phosphorylation.
@en
prefLabel
Regulation of protein kinase C ...... ated tyrosine phosphorylation.
@en
P2093
P2860
P356
P1476
Regulation of protein kinase C ...... ated tyrosine phosphorylation.
@en
P2093
P2860
P304
P356
10.1074/JBC.275.5.3603
P407
P577
2000-02-01T00:00:00Z