The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.
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The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryInteraction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase CIdentification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleMolecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformCrystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine bindingRegulation of T-cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during immunological synapse formationSpecific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A geneDelineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzaeHuman PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changebeta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to GiImpaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient micecAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in ratsInduction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responsesScanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cellPhosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthmaCharacterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationLong PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4.Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsThe unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4DAssessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytesEstimating the magnitude of near-membrane PDE4 activity in living cellsDownregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signalingAdjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.Involvement of type 4 cAMP-phosphodiesterase in the myogenic differentiation of L6 cells.Hypothetical membrane mechanisms in essential tremor.
P2860
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P2860
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The multienzyme PDE4 cyclic ad ...... ry and antidepressant actions.
@en
type
label
The multienzyme PDE4 cyclic ad ...... ry and antidepressant actions.
@en
prefLabel
The multienzyme PDE4 cyclic ad ...... ry and antidepressant actions.
@en
P1476
The multienzyme PDE4 cyclic ad ...... ry and antidepressant actions.
@en
P2093
P304
P577
1998-01-01T00:00:00Z