Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.
about
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorTwo PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activationDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseRole of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementA point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinaseTyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactionsA specific combination of substrates is involved in signal transduction by the kit-encoded receptor.Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue.A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigenMembrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation.A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce earlDelineation of functional determinants in the transforming protein of Fujinami sarcoma virus.Platelet-derived growth factor: mechanism of action and possible in vivo function.Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane rufflingStructural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinasePhosphatidylinositol 3-kinase.Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells.Altered regulation of platelet-derived growth factor A-chain and c-fos gene expression in senescent progeria fibroblasts.Structure-function studies of heparin-binding (acidic fibroblast) growth factor-1 using site-directed mutagenesis.Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S.
P2860
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P2860
Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Deletion of the kinase insert ...... ivity and signal transduction.
@en
type
label
Deletion of the kinase insert ...... ivity and signal transduction.
@en
prefLabel
Deletion of the kinase insert ...... ivity and signal transduction.
@en
P2093
P2860
P356
P1476
Deletion of the kinase insert ...... ivity and signal transduction.
@en
P2093
Claesson-Welsh L
Mellström K
Severinsson L
P2860
P304
P356
10.1128/MCB.10.2.801
P407
P577
1990-02-01T00:00:00Z