A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
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P110delta, a novel phosphoinositide 3-kinase in leukocytesCloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmanninMultiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translationAutophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivoCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeastInterleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell linesCarboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitroHeregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptorPhosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activityIonizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinaseDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseThe catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexesArginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptorA region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclaseATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cellsRho family GTPases bind to phosphoinositide kinases.Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter.A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.Phosphatidylinositol 3-kinases in tumor progression.Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylationAutophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activityThe structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling.Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling.Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memories.Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity.Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinaseYMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites.Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
P2860
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P2860
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@ast
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@en
type
label
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@ast
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@en
prefLabel
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@ast
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@en
P2093
P2860
P356
P1476
A tightly associated serine/th ...... hoinositide 3-kinase activity.
@en
P2093
B C Duckworth
B Schaffhausen
C L Carpenter
L C Cantley
P2860
P304
P356
10.1128/MCB.13.3.1657
P407
P577
1993-03-01T00:00:00Z