Destabilization of akt promotes the death of myeloma cell lines.

about

SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway

P2860

Q35761691-FED7D4F1-3530-4070-8C98-48EC8231B6D0

P2860

Destabilization of akt promotes the death of myeloma cell lines.

Item

http://www.wikidata.org/entity/Q41770644

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Destabilization of akt promotes the death of myeloma cell lines.

@en

type

Item

label

Destabilization of akt promotes the death of myeloma cell lines.

@en

prefLabel

Destabilization of akt promotes the death of myeloma cell lines.

@en

P1476

Destabilization of akt promotes the death of myeloma cell lines.

@en

P2093

Fan Zhang

http://www.w3.org/2001/XMLSchema#string

Jing Liu

http://www.w3.org/2001/XMLSchema#string

Yanan Zhang

http://www.w3.org/2001/XMLSchema#string

Yunfeng Fu

http://www.w3.org/2001/XMLSchema#string

P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

P304

190629

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1155/2014/190629

http://www.w3.org/2001/XMLSchema#string

P407

English

P478

2014

http://www.w3.org/2001/XMLSchema#string

P577

2014-08-31T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

266028374

http://www.w3.org/2001/XMLSchema#string

P698

25243120

http://www.w3.org/2001/XMLSchema#string

P932

4163362

http://www.w3.org/2001/XMLSchema#string

Destabilization of akt promotes the death of myeloma cell lines.

about

P2860

P2860

Destabilization of akt promotes the death of myeloma cell lines.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P478

P577

P5875

P698

P932