Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

Item

http://www.wikidata.org/entity/Q41779635

Q41779635

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l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells.High-level expression of human arginase I in Pichia pastoris and its immobilization on chitosan to produce L-ornithine Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy.Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma.Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.Development of systemic therapy for hepatocellular carcinoma at 2013: updates and insights.Recombinant arginine-degrading enzymes in metabolic anticancer therapy and bioanalytics.Arginine dependence of tumor cells: targeting a chink in cancer's armor.Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells.Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways.Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma.Deprivation of arginine by recombinant human arginase in prostate cancer cells.PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo.An intermolecular disulfide-based light switch for chloroplast psbD gene expression in Chlamydomonas reinhardtii.Expression, purification, and biochemical properties of arginase from Bacillus subtilis 168.

P2860

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P2860

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

Item

http://www.wikidata.org/entity/Q41779635

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

2009年论文

@zh

2009年论文

@zh-cn

name

Pegylated derivatives of recom ...... patocellular carcinoma cell (H

@en

type

Item

label

Pegylated derivatives of recom ...... patocellular carcinoma cell (H

@en

prefLabel

Pegylated derivatives of recom ...... patocellular carcinoma cell (H

@en

P1476

Pegylated derivatives of recom ...... ocellular carcinoma cell (HCC)

@en

P2093

Denys N Wheatley

http://www.w3.org/2001/XMLSchema#string

Hiu-Chi Chong

http://www.w3.org/2001/XMLSchema#string

Paul Ning-Man Cheng

http://www.w3.org/2001/XMLSchema#string

Pui-Kin So

http://www.w3.org/2001/XMLSchema#string

Simon Arnold

http://www.w3.org/2001/XMLSchema#string

Sui-Yi Kwok

http://www.w3.org/2001/XMLSchema#string

Tin-Lun Lam

http://www.w3.org/2001/XMLSchema#string

Wai-Hung Lo

http://www.w3.org/2001/XMLSchema#string

Wai-Man Lam

http://www.w3.org/2001/XMLSchema#string

P2860

In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

Pegylation: a novel process for modifying pharmacokinetics.

Chemistry for peptide and protein PEGylation.

Pegylated interferons.

Effect of pegylation on pharmaceuticals.

Pegvisomant Pfizer/Sensus.

Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents.

Structure and function of arginases.

Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures.

Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis.

P2888

1475-2867-9-9

P304

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1475-2867-9-9

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Yun-Chung Leung

Sam-Mui Tsui

P577

2009-04-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

24305867

http://www.w3.org/2001/XMLSchema#string

P6179

1018933074

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P698

19374748

http://www.w3.org/2001/XMLSchema#string

P932

2679726

http://www.w3.org/2001/XMLSchema#string

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

about

P2860

P2860

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P478

P50

P577

P5875

P6179

P698

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P478

P50

P577

P5875

P6179

P698

P932