Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. - Wikidata - wikimedia - TriplyDB

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.

http://www.wikidata.org/entity/Q41827780

about

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners Meprins, membrane-bound and secreted astacin metalloproteinases MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease Remodelling the extracellular matrix in development and disease Intestinal epithelium in inflammatory bowel disease MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury.A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14 Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease Meprin A metalloproteinase and its role in acute kidney injury.The bone morphogenetic protein 1/Tolloid-like metalloproteinases Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin β.IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines.Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.Meprin metalloproteases inactivate interleukin 6.Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.

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P2860

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.

http://www.wikidata.org/entity/Q41827780

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Human meprin alpha and beta ho ...... to metalloprotease inhibitors.

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type

label

Human meprin alpha and beta ho ...... to metalloprotease inhibitors.

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prefLabel

Human meprin alpha and beta ho ...... to metalloprotease inhibitors.

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P1433

Biochemical Journal

P1476

Human meprin alpha and beta ho ...... to metalloprotease inhibitors.

@en

P2093

Christoph Becker

http://www.w3.org/2001/XMLSchema#string

Daniel Lottaz

http://www.w3.org/2001/XMLSchema#string

Danny Köhler

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Erwin E Sterchi

http://www.w3.org/2001/XMLSchema#string

Hans-Willi Krell

http://www.w3.org/2001/XMLSchema#string

Irene Yiallouros

http://www.w3.org/2001/XMLSchema#string

Markus-N Kruse

http://www.w3.org/2001/XMLSchema#string

Walter Stöcker

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P2860

Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity

An old enzyme with a new function: purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin

The astacin family of metalloendopeptidases

The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

Structure of astacin with a transition-state analogue inhibitor

Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro

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383-389

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scholarly article

P356

10.1042/BJ20031163

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P407

P433

Pt 2

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P478

378

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Walter Stöcker

Hans-Willi Krell

P577

2004-03-01T00:00:00Z

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14594449

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1223953

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