Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
about
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkinParkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1Mouse Genetic Models of Human Brain DisordersEvaluation of Models of Parkinson's DiseaseInduced pluripotent stem cells in Parkinson's disease: scientific and clinical challengesMouse models of Parkinson's disease associated with mitochondrial dysfunctionGenetically engineered mouse models of Parkinson's diseaseMitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorderPotentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic StressA53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old miceParkinson's disease: animal models and dopaminergic cell vulnerabilityNeuronal Mitophagy in Neurodegenerative DiseasesAnimal models of Parkinson's disease: vertebrate geneticsBehavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse modelsDJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Parkinson's disease: insights from pathways.Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease.Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control.Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice.Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.Mitochondrial dysfunction in genetic animal models of Parkinson's diseaseMitochondrial dynamics and Parkinson's disease: focus on parkin.Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathwayThe Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.Mitochondria: the next (neurode)generationParkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal SurvivalDrosophila as a model to study mitochondrial dysfunction in Parkinson's disease.One-step generation of triple gene-targeted pigs using CRISPR/Cas9 systemThe roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseasePINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR.Autophagy and human diseases.Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.Changes in functional organization and white matter integrity in the connectome in Parkinson's disease.
P2860
Q24298771-F79C73AA-179B-45A5-B032-A7D6D24D732DQ24308897-3BA9963A-660C-4B67-B38B-2771EFF86FFDQ24315046-3FA1D1B1-4046-4AAA-A598-DD944D2C75FEQ26752246-0833B6D1-D3A8-4E48-A0BC-7DF8B921F9EFQ26772843-464DCB9C-B054-4767-A61D-6B68D68EDBD0Q26772879-644DCF6F-FF61-4D6E-B95B-663B3EB0994CQ26829851-D3827638-EDA2-4B4C-8D71-A670D450BF9DQ26852964-5BEBFE1A-8E8C-470C-B49D-A6D5FC54DF5FQ27001551-19A92CEC-77F6-42E2-B32C-8E8D22196DEAQ27301199-F5B0DC64-7C85-48EA-A271-4007B8040390Q27305291-94EDE403-01C0-40C3-A1C1-04274574BFFAQ27324171-EF47DDD8-EA77-44AC-9682-F1E2CB8FF87EQ28080503-CE83F68E-A6AA-42CF-8D14-E6A2DD9E5C2DQ29248361-2057BC0F-3F0D-438A-81CF-E1C690D7D011Q30429583-C8C95032-F745-44A6-AA0E-202C3F43B631Q30444939-530C1F30-75EE-41E1-A0EE-6CE493ABD5CEQ33735667-736907A7-9B57-4E5B-9DC7-F7CA65393A87Q33746268-16626EFE-A0CA-48EF-A8CF-3BADC9C2FC7AQ33755817-360C881A-544C-4C74-9DA5-829122259950Q33871291-AA7D943D-A5E3-4422-9321-55D0B5BC998EQ34119144-3CCD2AD2-3A3F-4402-B5FB-F53B734FEF37Q34805850-CE93F328-E0A1-424A-ABF3-3F0E1EA1CFB5Q35147827-13DDD1EE-8EF9-4FD4-85FA-8A7628C5ECEEQ35208410-E2CC06E8-5A2B-463E-B7A4-299CC5FD3702Q35479978-DE84945A-194F-40E3-9570-C35F53F3F339Q35589979-74AC1EBC-A063-438C-AE2D-05A09E26A696Q35799109-063900A7-C72D-421A-9F7B-9241CE9636F1Q35799161-0141B285-F2D9-47BA-886A-44AA49346F7AQ35811884-390BA850-774C-4AB3-A252-AAF2A7AC54D2Q36103249-F0E82031-C8E7-4E8C-97F7-08D5E6E5413DQ36124905-46689F09-A09E-47FF-8524-D9B1CA94C628Q36186542-8E0CD728-DF90-4954-922C-306582D8C963Q36381932-F4BD372A-CC28-47F3-A9C9-6ED1D06AF571Q36526622-05EF34DB-935B-4F4A-B5FB-69B16467739AQ36560195-D099B35D-1962-4884-8D35-A3C67BEAEC74Q36611426-6F898820-527D-4685-9D0B-1721392B834BQ36852642-3115A649-4E64-44B5-AEE5-1EBA597467ACQ37429062-10702205-D3D9-42FA-BD04-DFDCA2559756Q37509682-32855736-1690-4BD0-A23D-1E224904D307Q37580673-CC06A1E4-C9ED-4D24-9AA5-9CC325C8C2B7
P2860
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
@en
type
label
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
@en
prefLabel
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
@en
P2093
P2860
P1476
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.
@en
P2093
Clement A Gautier
Tohru Kitada
Youren Tong
P2860
P304
P356
10.1111/J.1471-4159.2009.06350.X
P407
P577
2009-08-19T00:00:00Z