Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.
about
Gene therapy: therapeutic gene causing lymphomaNovel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.IRF4 is a suppressor of c-Myc induced B cell leukemia.Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemiaMimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cellsPhysical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtkBLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.The effects of c-Abl mutation on developing B cell differentiation and survivalIbrutinib and novel BTK inhibitors in clinical development.The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.BTK Signaling in B Cell Differentiation and Autoimmunity.From identification of the BTK kinase to effective management of leukemia.Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion.Identification and characterization of a novel BASH N terminus-associated protein, BNAS2.Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.BTK blocks the inhibitory effects of MDM2 on p53 activity.Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia.Role of Bruton's tyrosine kinase in B cells and malignancies.Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: a new approach for target discovery.Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.BTK modulates p73 activity to induce apoptosis independently of p53
P2860
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P2860
Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Bruton's tyrosine kinase coope ...... mor suppressor in Pre-B cells.
@en
type
label
Bruton's tyrosine kinase coope ...... mor suppressor in Pre-B cells.
@en
prefLabel
Bruton's tyrosine kinase coope ...... mor suppressor in Pre-B cells.
@en
P2093
P2860
P356
P1476
Bruton's tyrosine kinase coope ...... umor suppressor in Pre-B cells
@en
P2093
Gemma M Dingjan
Hassan Jumaa
Katarina Dahlenborg
Michael Reth
Rogier Kersseboom
Rudolf W Hendriks
P2860
P356
10.1084/JEM.20030615
P407
P577
2003-06-30T00:00:00Z