Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. - Wikidata - wikimedia - TriplyDB

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

http://www.wikidata.org/entity/Q41887614

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Mending a broken heart: the role of mitophagy in cardioprotection The two faces of miR-29 The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death Recent advances in mitochondrial research A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy Mitochondrial quality control in the myocardium: cooperation between protein degradation and mitophagy Regulation of cardiac expression of the diabetic marker microRNA miR-29 Differential Effects of β-Blockers, Angiotensin II Receptor Blockers, and a Novel AT2R Agonist NP-6A4 on Stress Response of Nutrient-Starved Cardiovascular Cells Inhibition of miR-302 Suppresses Hypoxia-Reoxygenation-Induced H9c2 Cardiomyocyte Death by Regulating Mcl-1 Expression Mcl-1 ubiquitination: unique regulation of an essential survival protein.Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.Autophagy and oxidative stress in cardiovascular diseases.The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.Functions of autophagy in pathological cardiac hypertrophy The COP9 signalosome and cullin-RING ligases in the heart Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.MicroRNA-128 inhibition attenuates myocardial ischemia/reperfusion injury-induced cardiomyocyte apoptosis by the targeted activation of peroxisome proliferator-activated receptor gamma.Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 Urinary Exosomal miR-193a Can Be a Potential Biomarker for the Diagnosis of Primary Focal Segmental Glomerulosclerosis in Children.Autophagy and mitophagy in the myocardium: therapeutic potential and concerns.Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy.Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis.Screening Feature Genes of Venous Thromboembolism with DNA Microarray.Mitochondrial apoptosis: killing cancer using the enemy within.Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax.Targeting cell death signalling in cancer: minimising 'Collateral damage'.Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1.EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.Survival control of malignant lymphocytes by anti-apoptotic MCL-1.Therapeutic inhibition of BCL-2 and related family members.

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P2860

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

http://www.wikidata.org/entity/Q41887614

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

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type

label

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

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prefLabel

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

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Genes & Development

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Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

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P2093

David J Roberts

http://www.w3.org/2001/XMLSchema#string

Dieter A Kubli

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Jarvis B Owens

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Kimberlee M Fischer

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Mark A Sussman

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Melissa N Quinsay

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Robert L Thomas

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Shigeki Miyamoto

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Youngil Lee

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Åsa B Gustafsson

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

Identification of regulators of chaperone-mediated autophagy

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

Mitochondria and mitophagy: the yin and yang of cell death control

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1365-1377

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10.1101/GAD.215871.113

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12

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27

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23788623

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