Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction - Wikidata - wikimedia - TriplyDB

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

http://www.wikidata.org/entity/Q41908763

about

Somatic hypermutation of the AID transgene in B and non-B cells How I treat autoimmune lymphoproliferative syndrome AID/APOBEC deaminases and cancer Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations AID targeting: old mysteries and new challenges AID and Apobec3G haphazard deamination and mutational diversity Molecular portraits of B cell lineage commitment.Rituximab responsive immune thrombocytopenic purpura in an adult with underlying autoimmune lymphoproliferative syndrome due to a splice-site mutation (IVS7+2 T>C) affecting the Fas gene.Role of the translocation partner in protection against AID-dependent chromosomal translocations Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Attracting AID to targets of somatic hypermutation.Origin of chromosomal translocations in lymphoid cancer.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.RETRACTED: Silencing of B cell receptor signals in human naive B cells.Msh6 protects mature B cells from lymphoma by preserving genomic stability.AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Mechanisms of chromosomal translocations in B cell lymphomas.Targeting of somatic hypermutation.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.AID and mismatch repair in antibody diversification.Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Complex regulation and function of activation-induced cytidine deaminase.Life and death within germinal centres: a double-edged sword.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.What role for AID: mutator, or assembler of the immunoglobulin mutasome?The ontogeny and fate of NK cells marked by permanent DNA rearrangements.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.Mechanisms of B-cell lymphoma pathogenesis.A role for AID in chromosome translocations between c-myc and the IgH variable region.Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Proteasomal degradation restricts the nuclear lifespan of AID Mutations within the 5' region of FAS/CD95 gene in nodal diffuse large B-cell lymphoma.

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P2860

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

http://www.wikidata.org/entity/Q41908763

description

2000 nî lūn-bûn

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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2000年论文

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2000年论文

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Somatic mutation of the CD95 g ...... f the germinal center reaction

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Somatic mutation of the CD95 g ...... f the germinal center reaction

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B Jungnickel

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M Müschen

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P2860

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cells

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

Cellular origin of human B-cell lymphomas.

Defining CD95 as a tumor suppressor gene.

Pathological findings in human autoimmune lymphoproliferative syndrome

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.

Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.

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