Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism
about
The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pHSeveral cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferaseUrokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22Molecular mechanisms for the conversion of zymogens to active proteolytic enzymesCrystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interestStructural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidaseProteolytic Activation of Human Cathepsin AStaphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of ActivationMolecular markers of serine protease evolutionStructure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism.Threading with chemostructural restrictions method for predicting fold and functionally significant residues: application to dipeptidylpeptidase IV (DPP-IV).Structural trees for protein superfamilies.The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis.Stable expression of protective protein/cathepsin A-green fluorescent protein fusion genes in a fibroblastic cell line from a galactosialidosis patient. Model system for revealing the intracellular transport of normal and mutated lysosomal enzymes.Lysosomal multienzyme complex: pros and cons of working togetherInhibition of CatA: an emerging strategy for the treatment of heart failure.Molecular mechanisms of pathogenesis in a glycosphingolipid and a glycoprotein storage diseaseThe metabolic serine hydrolases and their functions in mammalian physiology and disease.Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization.Galactosialidosis: historic aspects and overview of investigated and emerging treatment options.Lysosomal neuraminidase. Catalytic activation in insect cells is controlled by the protective protein/cathepsin A.Endocytosis and Enamel Formation.Development of transgenic Brassica juncea lines for reduced seed sinapine content by perturbing phenylpropanoid pathway genesCathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.Ser(214) is crucial for substrate binding to serine proteases.Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.Molecular Cloning, Characterization, and Expression Analysis of Cathepsin A in the Chinese Giant Salamander Andrias davidianus.Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)NEU1;4 hydrolyses Neu5Ac from glycoconjugatesLysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients
P2860
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P2860
Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Three-dimensional structure of ...... a complex activation mechanism
@ast
Three-dimensional structure of ...... a complex activation mechanism
@en
Three-dimensional structure of ...... a complex activation mechanism
@nl
type
label
Three-dimensional structure of ...... a complex activation mechanism
@ast
Three-dimensional structure of ...... a complex activation mechanism
@en
Three-dimensional structure of ...... a complex activation mechanism
@nl
prefLabel
Three-dimensional structure of ...... a complex activation mechanism
@ast
Three-dimensional structure of ...... a complex activation mechanism
@en
Three-dimensional structure of ...... a complex activation mechanism
@nl
P2093
P1433
P1476
Three-dimensional structure of ...... a complex activation mechanism
@en
P2093
P304
P356
10.1016/S0969-2126(01)00260-X
P577
1995-11-15T00:00:00Z