The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. - Wikidata - wikimedia - TriplyDB

The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.

The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.

http://www.wikidata.org/entity/Q42061406

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Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeast Solution Structure of Polymerase μ's BRCT Domain Reveals an Element Essential for Its Role in Nonhomologous End Joining †Interaction between DNA Polymerase and Anticancer Nucleoside Analogs A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ Msl2 is a novel component of the vertebrate DNA damage response Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.Involvement of AtPolλ in the repair of high salt- and DNA cross-linking agent-induced double strand breaks in Arabidopsis.A novel mechanism of sugar selection utilized by a human X-family DNA polymerase.Sequence conversion by single strand oligonucleotide donors via non-homologous end joining in mammalian cells DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways Identification of critical residues for the tight binding of both correct and incorrect nucleotides to human DNA polymerase λ N-terminal domains of human DNA polymerase lambda promote primer realignment during translesion DNA synthesis.Modeling DNA polymerase μ motions: subtle transitions before chemistry.A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation DNA repair mechanisms in dividing and non-dividing cells.Yeast pol4 promotes tel1-regulated chromosomal translocations.DNA pol λ's extraordinary ability to stabilize misaligned DNA.Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration of a transgene.Essential role for polymerase specialization in cellular nonhomologous end joining.Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.Alternative endings.DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.Multiple functions of DNA polymerases.Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends The 3'-to-5' exonuclease activity of vaccinia virus DNA polymerase is essential and plays a role in promoting virus genetic recombination.Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting Relationship between conformational changes in pol lambda's active site upon binding incorrect nucleotides and mismatch incorporation rates.Polymerases in nonhomologous end joining: building a bridge over broken chromosomes.Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.DNA polymerases in nonhomologous end joining: are there any benefits to standing out from the crowd?Mouse models of DNA polymerases.Repair of double-strand breaks by end joining.

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The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.

http://www.wikidata.org/entity/Q42061406

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2006 nî lūn-bûn

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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Nucleic Acids Research

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The DNA polymerase lambda is r ...... ks by NHEJ in mammalian cells.

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Audrey Laroche-Clary

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Christophe Cazaux

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François Boudsocq

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Jean-Pascal Capp

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Jean-Sébastien Hoffmann

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Pascale Bertrand

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Philippe Pourquier

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Yvan Canitrot

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P2860

Processing of DNA for nonhomologous end-joining by cell-free extract

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

DNA polymerase lambda can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4-ligase IV complex.

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining.

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.

Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis

Chromosomal stability and the DNA double-stranded break connection

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2998-3007

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10.1093/NAR/GKL380

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10

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34

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7045039

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16738138

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1474058

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