about
Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexViral infection and human disease--insights from minimotifsRapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cellsAlterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyGenetic perspective of retinoblastoma: From present to futureDiffuse anterior retinoblastoma: current conceptsTwists in views on RB functions in cellular signaling, metabolism and stem cellsTo live or let die - complexity within the E2F1 pathwayRB1: a prototype tumor suppressor and an enigmaGenome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer riskUnderstanding pRb: toward the necessary development of targeted treatments for retinoblastomaCrystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational ChangesStructure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMXThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetMultimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and developmentThe pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noiseMDM2 and MDMX: Alone and together in regulation of p53Coexpression of normally incompatible developmental pathways in retinoblastoma genesisMDM4 (MDMX) and its Transcript Variants.Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivityA new protein linear motif benchmark for multiple sequence alignment softwareE2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.Genomic differences between retinoma and retinoblastoma.Identification and characterization of the first small molecule inhibitor of MDMXHigh Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblastsTargeting p53 for Novel Anticancer Therapy.The regulation of the p53-mediated stress response by MDM2 and MDM4.Tumorigenesis promotes Mdm4-S overexpression.Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glioma model.Retinoblastoma: one world, one visionMutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counsellingGenetic and Epigenetic Discoveries in Human RetinoblastomaNovel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsMDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transportMDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Inactivation of the p53 pathway in retinoblastoma.
@en
Inactivation of the p53 pathway in retinoblastoma.
@nl
type
label
Inactivation of the p53 pathway in retinoblastoma.
@en
Inactivation of the p53 pathway in retinoblastoma.
@nl
prefLabel
Inactivation of the p53 pathway in retinoblastoma.
@en
Inactivation of the p53 pathway in retinoblastoma.
@nl
P2093
P2860
P50
P356
P1433
P1476
Inactivation of the p53 pathway in retinoblastoma
@en
P2093
Aart G Jochemsen
Adithi Mohan
Amina Teunisse
Carlos Rodriguez-Galindo
Chie-Schin Shih
Christine Fuller
Dianna Johnson
Jiakun Zhang
Matthew Wilson
Micaela Quarto
P2860
P2888
P356
10.1038/NATURE05194
P407
P577
2006-11-01T00:00:00Z
P5875
P6179
1051876514