Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.

Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.

Item
http://www.wikidata.org/entity/Q42182053
Conotoxins targeting nicotinic acetylcholine receptors: an overviewA novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV currentNicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype.Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.α9-containing nicotinic acetylcholine receptors and the modulation of pain.RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-ylCrystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl.Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl.Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.
P2860

Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.

Item
http://www.wikidata.org/entity/Q42182053
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@en
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@nl
type
label
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@en
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@nl
prefLabel
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@en
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
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P1433
P1476
Discovery of non-peptide, smal ...... c and tonic inflammatory pain.
@en
P2093
P2860
P304
P31
P356
10.1016/J.BMCL.2011.02.043
P407
P433
P478
P577
P698
P921
P932