Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans - Wikidata - wikimedia - TriplyDB

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

http://www.wikidata.org/entity/Q42247172

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Insulin resistance is a cellular antioxidant defense mechanism Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?The rise of mitochondria in medicine Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?Redox implications in adipose tissue (dys)function--A new look at old acquaintances Neuroinflammatory basis of metabolic syndrome Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?Genetics of oxidative stress in obesity Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies Mitochondria and cardiovascular aging Emerging role of protein kinase C in energy homeostasis: A brief overview Mitochondrial oxidative stress in aging and healthspan Can antioxidants protect against disuse muscle atrophy?Clinical effects of high-fat meals and weight gain due to high-fat feeding Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice Sugar consumption, metabolic disease and obesity: The state of the controversy Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics Serendipity and the discovery of novel compounds that restore mitochondrial plasticity Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin Mitochondrial hormesis and diabetic complications Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise Mitochondrial health, the epigenome and healthspan Protective mechanisms of mitochondria and heart function in diabetes Mitochondrial stress signaling promotes cellular adaptations Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling Signal transduction by reactive oxygen species High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

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Chien-Te Lin

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Daniel A Kane

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David H Wasserman

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Ethan J Anderson

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Hazel H Szeto

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Jesse W Price

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Joseph A Houmard

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Li Kang

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Mary E Lustig

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P Darrell Neufer

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P2860

Inflammation, stress, and diabetes

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Extension of murine life span by overexpression of catalase targeted to mitochondria

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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10.1172/JCI37048

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Kristen E. Boyle

P S Rabinovitch

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2009-02-02T00:00:00Z

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23972770

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19188683

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