Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
about
The alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionNMR Methods to Study Dynamic AllosteryRegulation of small GTPases by GEFs, GAPs, and GDIsStructural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AFAn Autoinhibited State in the Structure of Thermotoga maritima NusGStructural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD fromKlebsiella pneumoniaeCracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsLigand binding and self-association cooperativity of β-lactoglobulinDifferential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysisThe role of dynamic conformational ensembles in biomolecular recognitionTyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Protein activity regulation by conformational entropy.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.Automated electron-density sampling reveals widespread conformational polymorphism in proteinsMolecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.Intrinsically disordered proteins in cellular signalling and regulation.Tuning protein autoinhibition by domain destabilizationInterdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.Vav1 GEF activity is required for T cell mediated allograft rejectionComplete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis.Proteasome allostery as a population shift between interchanging conformersVisualizing transient low-populated structures of RNA.Analysis of Multidomain Protein Dynamics.Hidden dynamic allostery in a PDZ domain.Sending signals dynamically.Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae.Vav1 as a central regulator of invadopodia assemblyNMR studies of nucleic acid dynamicsNMR reveals novel mechanisms of protein activity regulation.Electrostatics in proteins and protein-ligand complexes.Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivoPressure-A Gateway to Fundamental Insights into Protein Solvation, Dynamics, and Function.Protein dynamics and function from solution state NMR spectroscopy.
P2860
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P2860
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@en
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@nl
type
label
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@en
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@nl
prefLabel
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@en
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@nl
P2093
P2860
P356
P1476
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
@en
P2093
Ilídio R S Martins
Michael K Rosen
P2860
P2888
P304
P356
10.1038/NSMB.1428
P577
2008-05-18T00:00:00Z