Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.
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Genomic Plasticity of the Human Fungal Pathogen Candida albicansHypoxia and fungal pathogenesis: to air or not to air?Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways.Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonA sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatusAcquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistanceThe transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansZinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolutionA novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulationDevelopment of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses.Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicansEnvironmental induction of white-opaque switching in Candida albicans.Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicansSterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesisSynergistic regulation of hyphal elongation by hypoxia, CO(2), and nutrient conditions controls the virulence of Candida albicansThe role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity.UPC2 is universally essential for azole antifungal resistance in Candida albicans.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights.Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosisDisruption of the transcriptional regulator Cas5 results in enhanced killing of Candida albicans by FluconazoleRegulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles.Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.The evolution of drug resistance in clinical isolates of Candida albicansComparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicansSREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).Transcription factor ADS-4 regulates adaptive responses and resistance to antifungal azole stressMultidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis.Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene.Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.Function and Regulation of Cph2 in Candida albicans.Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans.Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi.A fungal family of transcriptional regulators: the zinc cluster proteinsA gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.
P2860
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P2860
Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@en
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@nl
type
label
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@en
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@nl
prefLabel
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@en
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@nl
P2093
P2860
P1476
Candida albicans zinc cluster ...... ergosterol biosynthetic genes.
@en
P2093
Bassel Akache
Bernard Turcotte
Martine Raymond
Sandra Weber
Sarah MacPherson
Xavier De Deken
P2860
P304
P356
10.1128/AAC.49.5.1745-1752.2005
P407
P577
2005-05-01T00:00:00Z