GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism.
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Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncouplingMapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytesInsulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesGLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistanceIdentification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane.Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membraneThe GLUT4 codeHigh basal cell surface levels of fish GLUT4 are related to reduced sensitivity of insulin-induced translocation toward GGA and AS160 inhibition in adipocytes.Insulin-regulated Glut4 translocation: membrane protein trafficking with six distinctive steps.Reciprocal regulation of endocytosis and metabolismTyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistanceA naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivityA novel method for simulating insulin mediated GLUT4 translocation.Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.Dual-mode of insulin action controls GLUT4 vesicle exocytosis.Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinaseGLUT4 exocytosis.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.Studying lipolysis in adipocytes by combining siRNA knockdown and adenovirus-mediated overexpression approaches.Insulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.Ins (endocytosis) and outs (exocytosis) of GLUT4 traffickingOptogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.Will the original glucose transporter isoform please stand up!Biogenesis and regulation of insulin-responsive vesicles containing GLUT4.Posttranslational modifications of GLUT4 affect its subcellular localization and translocation.Homeostatic signaling and the stabilization of neural function.Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance.Muscling in on GLUT4 kinetics.Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.Molecular mechanisms controlling GLUT4 intracellular retention.GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin.Development of a quantitative Correlative Light Electron Microscopy technique to study GLUT4 trafficking.Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility.Insulin releases Glut4 from static storage compartments into cycling endosomes and increases the rate constant for Glut4 exocytosis.Molecular basis of insulin-responsive GLUT4 trafficking systems revealed by single molecule imaging.
P2860
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P2860
GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@en
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@nl
type
label
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@en
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@nl
prefLabel
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@en
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@nl
P2093
P2860
P356
P1476
GLUT4 distribution between the ...... d bipartite dynamic mechanism.
@en
P2093
Adrian Lee
Ola J Martin
Timothy E McGraw
P2860
P304
P356
10.1074/JBC.M505944200
P407
P577
2005-11-02T00:00:00Z