Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.
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Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathwayInsulin regulates Glut4 confinement in plasma membrane clusters in adipose cellsDesign, generation, and testing of mammalian expression modules that tag membrane proteinsIdentification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cellsProtein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transportAS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membraneTBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytesInsulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inThe inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.GLUT4 exocytosis.The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocationAssociation between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cellsPotential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.Insulin receptor regulates photoreceptor CNG channel activity.Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.N-glycosylation is critical for the stability and intracellular trafficking of glucose transporter GLUT4Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrationsMuscling in on GLUT4 kinetics.Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells.Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal.FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways.Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific inPossible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4.Roles of insulin, guanosine 5'-[gamma-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation.Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells.Endocytosis of the glucose transporter GLUT4 is mediated by the GTPase dynamin.Overexpression of the glucose transporter GLUT4 in adipose cells interferes with insulin-stimulated translocation.GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism.Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism.Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes.Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway.Comparative effects of GTPgammaS and insulin on the activation of Rho, phosphatidylinositol 3-kinase, and protein kinase N in rat adipocytes. Relationship to glucose transport.GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation.Epitope tagging permits cell surface detection of functional CFTR.Translocation and Redistribution of GLUT4 Using a Dual-Labeled Reporter Assay.
P2860
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P2860
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@ast
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@en
type
label
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@ast
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@en
prefLabel
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@ast
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@en
P2093
P2860
P356
P1476
Tyrosine kinase-deficient muta ...... ation of epitope-tagged GLUT4.
@en
P2093
Cushman SW
Guerre-Millo M
Zarnowski MJ
P2860
P304
P356
10.1073/PNAS.91.12.5587
P407
P577
1994-06-01T00:00:00Z