A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. - Wikidata - wikimedia - TriplyDB

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

http://www.wikidata.org/entity/Q42521789

about

Single-gene mutations and healthy ageing in mammals FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis Distinct signaling functions for Shc isoforms in the heart Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Antagonism of p66shc by melanoma inhibitory activity.Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro.Cytochrome c signalosome in mitochondria.FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.P66Shc signals to age.Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?Monoamine oxidases as sources of oxidants in the heart p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination p53 and mitochondrial function in neurons.Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance.Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.P66SHC and ageing: ROS and TOR?The influence of Shc proteins on life span in mice.Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.

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P2860

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

http://www.wikidata.org/entity/Q42521789

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

@en

A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

@nl

type

label

A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

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A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

@nl

prefLabel

A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

@en

A p53-p66Shc signalling pathwa ...... tive stress-induced apoptosis.

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A p53-p66Shc signalling pathwa ...... ative stress-induced apoptosis

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Andrea Ventura

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Angelo Cicalese

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Elisabetta Milia

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Enrica Migliaccio

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Ines Martin Padura

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Marco Maccarana

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Mirella Trinei

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Pier Giuseppe Pelicci

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Sara Barozzi

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Saverio Minucci

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scholarly article

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10.1038/SJ.ONC.1205513

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24

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21

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Valeria Petronilli

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2002-05-01T00:00:00Z

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11339366

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