Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
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The Role of the Membrane-Initiated Heat Shock Response in CancerThe human HSP70 family of chaperones: where do we stand?The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug bindingSmall-molecule inhibitors of protein-protein interactions: progressing toward the reality.A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseasesKnockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Allosteric heat shock protein 70 inhibitors block hepatitis C virus assemblyDynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes.Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis.Targeting mitochondrial function for the treatment of breast cancer.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of TauopathyProtein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis.The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition.Hsp70: A Cancer Target Inside and Outside the Cell.Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells.Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.Chaperone substrate provides missing link for cancer drug discovery.Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs.Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma.High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex.Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.Repurposing drugs to target the malaria parasite unfolding protein response.
P2860
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P2860
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@en
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@nl
type
label
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@en
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@nl
prefLabel
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@en
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@nl
P2093
P2860
P356
P1476
Analogs of the Allosteric Heat ...... KT-077, as Anti-Cancer Agents.
@en
P2093
Adam M Kabza
Atta Ahmad
Erik R P Zuiderweg
Jamie Connarn
Jason E Gestwicki
Sharan R Srinivasan
Xiaokai Li
Zapporah T Young
P2860
P356
10.1021/ML400204N
P577
2013-11-01T00:00:00Z