Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.
about
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsA 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastCompetency for nonsense-mediated reduction in collagen X mRNA is specified by the 3' UTR and corresponds to the position of mutations in Schmid metaphyseal chondrodysplasiaEvolutionarily conserved and diverged alternative splicing events show different expression and functional profiles.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastNMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae.Posttranscriptional control of gene expression in yeast.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissuesThe uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).Regulation of AUF1 expression via conserved alternatively spliced elements in the 3' untranslated regionmRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frameAt least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stabilityRibosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.Nonsense-mediated decay of human HEXA mRNA.Is there a classical nonsense-mediated decay pathway in trypanosomes?T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts.Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay.Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitutionSMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.Regulation of glucose-dependent gene expression by the RNA helicase Dbp2 in Saccharomyces cerevisiae.RNA interference: advances and questions.A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated regionThe Upf-dependent decay of wild-type PPR1 mRNA depends on its 5'-UTR and first 92 ORF nucleotidesNonsense-mediated mRNA decay in Saccharomyces cerevisiae: a quality control mechanism that degrades transcripts harboring premature termination codons.Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay.Evolution of coding microsatellites in primate genomes.SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegansIdentification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.The structure and function of the rous sarcoma virus RNA stability element.mRNA quality control pathways in Saccharomyces cerevisiae.NMD mechanism and the functions of Upf proteins in plant.Infrequent translation of a nonsense codon is sufficient to decrease mRNA level
P2860
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P2860
Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@ast
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@en
type
label
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@ast
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@en
prefLabel
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@ast
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@en
P2093
P2860
P356
P1433
P1476
Identifying the right stop: de ...... and degrades an aberrant mRNA.
@en
P2093
C I González
M J Ruiz-Echevarría
P2860
P304
P356
10.1093/EMBOJ/17.2.575
P407
P577
1998-01-01T00:00:00Z