Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.
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ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversalStructure of P-glycoprotein reveals a molecular basis for poly-specific drug bindingBypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia TherapyThe Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutolInteraction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Identification, mutagenesis, and transcriptional analysis of the methanesulfonate transport operon of Methylosulfonomonas methylovora.3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.Distinct conformational spectrum of homologous multidrug ABC transporters.Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF.ATP release via anion channels.New horizon of MDR1 (P-glycoprotein) study.The translocation mechanism of P-glycoprotein.Insight in eukaryotic ABC transporter function by mutation analysis.Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)Mechanisms and strategies to overcome multiple drug resistance in cancer.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.On the origin of large flexibility of P-glycoprotein in the inward-facing stateFuture directions for drug transporter modelling.CLC-0 and CFTR: chloride channels evolved from transporters.Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos.Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbADiscovery of novel antitumor antimitotic agents that also reverse tumor resistance.Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.Multidrug efflux pumps: drug binding--gates or cavity?Cystic fibrosis transmembrane conductance regulator (ABCC7) structureStructure-activity relationships and in silico models of P-glycoprotein (ABCB1) inhibitors.Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.Overcoming multidrug resistance with nanomedicines.Structure of a human multidrug transporter in an inward-facing conformation.Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier.The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.ESCRT-mediated vesicle concatenation in plant endosomes.The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.
P2860
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P2860
Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Three-dimensional structures o ...... mains upon nucleotide binding.
@en
Three-dimensional structures o ...... mains upon nucleotide binding.
@nl
type
label
Three-dimensional structures o ...... mains upon nucleotide binding.
@en
Three-dimensional structures o ...... mains upon nucleotide binding.
@nl
prefLabel
Three-dimensional structures o ...... mains upon nucleotide binding.
@en
Three-dimensional structures o ...... mains upon nucleotide binding.
@nl
P2093
P2860
P356
P1476
Three-dimensional structures o ...... mains upon nucleotide binding.
@en
P2093
Alhaji Bukar Kamis
Christopher F Higgins
Mark F Rosenberg
P2860
P304
P356
10.1074/JBC.M211758200
P407
P577
2002-12-25T00:00:00Z