An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
about
An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1.Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock proteinBAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrateCharge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm traffickingUSP10 regulates p53 localization and stability by deubiquitinating p53Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasmMAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agentsSpecific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitinationMdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.Regulation of human p53 activity and cell localization by alternative splicingRegulation of p53 tetramerization and nuclear export by ARCEndoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaMammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferationMdm2 targets the p53 transcription cofactor JMY for degradationTyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationAnalysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionVisualization and targeted disruption of protein interactions in living cellsLigand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsCancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationPhosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts.DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export.Dysregulation of ubiquitin ligases in cancerDual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ storeMDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)Direct interactions between HIF-1 alpha and Mdm2 modulate p53 functionInhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ationATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damageActivation and activities of the p53 tumour suppressor proteinNT4(Si)-p53(N15)-antennapedia induces cell death in a human hepatocellular carcinoma cell lineThe Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer riskDeacetylation of p53 induces autophagy by suppressing Bmf expressionSCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathwayMDM2 and MDMX: Alone and together in regulation of p53p53 ubiquitination: Mdm2 and beyondUdu deficiency activates DNA damage checkpoint.Nucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3C-terminal ubiquitination of p53 contributes to nuclear export
P2860
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P2860
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@en
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@nl
type
label
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@en
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@nl
prefLabel
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@en
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@nl
P356
P1433
P1476
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
@en
P2093
P2888
P304
P356
10.1038/35023500
P577
2000-09-01T00:00:00Z