Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
about
Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growthPhosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnoverPhosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesisRegulation of c-SRC activity and function by the adapter protein CASRapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsSRChing for the substrates of Src.Phosphatidylinositol 3-kinases in tumor progression.RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.Sensing the environment: a historical perspective on integrin signal transduction.Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells.Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cellsRegulation of cell contraction and membrane ruffling by distinct signals in migratory cells.ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases.Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathwayAbnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans.Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases.Insulin-like growth factor 1 increases apical fibronectin in blastocysts to increase blastocyst attachment to endometrial epithelial cells in vitro.Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.Spatial and temporal regulation of focal adhesion kinase activity in living cells.Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis.Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1.Focal adhesion kinase tyrosine phosphorylation is associated with myogenesis and modulated by insulin.Leptin activation of ATP-sensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton.Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor.Signature microRNAs in human cornea limbal epithelium.Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation.Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397.Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells.Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.ANG II stimulation of neuritogenesis involves protein kinase B in brain neurons.
P2860
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P2860
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@en
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@nl
type
label
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@en
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@nl
prefLabel
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@en
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@nl
P356
P1476
Insulin-like growth factor I s ...... on of a p130(Cas).Crk complex.
@en
P2093
A Casamassima
E Rozengurt
P304
26149-26156
P356
10.1074/JBC.273.40.26149
P407
P577
1998-10-01T00:00:00Z