Distinct roles for DH and PH domains in the Lbc oncogene.
about
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPasesBiological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteinsActivation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targetingMembrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformationOligomerization of DH domain is essential for Dbl-induced transformationIdentification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeletonStructural Mechanisms and Drug Discovery Prospects of Rho GTPasesStructural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) OncoproteinStructure and mutagenesis of the Dbl homology domainThe crystal structure of the RhoA-AKAP-Lbc DH-PH domain complexAKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formationTrp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factorsActivation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorInteraction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarityLoss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targetingCcpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor DbsSpatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Autoinhibition mechanism of proto-Dbl.Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation.The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Modulation of HIV-1 replication by a novel RhoA effector activity.The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicityGuanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13.Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation.The Rho exchange factor Net1 is regulated by nuclear sequestration.Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins
P2860
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P2860
Distinct roles for DH and PH domains in the Lbc oncogene.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Distinct roles for DH and PH domains in the Lbc oncogene.
@en
Distinct roles for DH and PH domains in the Lbc oncogene.
@nl
type
label
Distinct roles for DH and PH domains in the Lbc oncogene.
@en
Distinct roles for DH and PH domains in the Lbc oncogene.
@nl
prefLabel
Distinct roles for DH and PH domains in the Lbc oncogene.
@en
Distinct roles for DH and PH domains in the Lbc oncogene.
@nl
P2093
P356
P1433
P1476
Distinct roles for DH and PH domains in the Lbc oncogene.
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1201594
P407
P577
1997-12-01T00:00:00Z
P5875
P6179
1048984957