Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
about
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolatesMolecular action of methotrexate in inflammatory diseasesAdenosine receptors: therapeutic aspects for inflammatory and immune diseases.Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature reviewHuman 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activityThe kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channelingPolyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritisInhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugsBioactivity of [6R]-5-formyltetrahydrofolate, an unusual isomer, in humans and Enterococcus hirae, and cytochrome c oxidation of 10-formytetrahydrofolate to 10-formyldihydrofolateCofactor role for 10-formyldihydrofolic acidThe antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?Pharmacogenetics and folate metabolism -- a promising direction.Atopic dermatitis: review of immunopathogenesis and advances in immunosuppressive therapy.High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.Molecular mechanism of methotrexate action in inflammation.Regulatory role of oxidized and reduced pteroylpolyglutamates.Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study.Resistance to antifolates.Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression.Methotrexate modulates the kinetics of adenosine in humans in vivo.Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.Mechanisms of induction of adenosine receptor genes and its functional significance.Reduction in Serum Uric Acid May Be Related to Methotrexate Efficacy in Early Rheumatoid Arthritis: Data from the Canadian Early Arthritis Cohort (CATCH).Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental DiabetesMarkers of treatment response to methotrexate in rheumatoid arthritis: where do we stand?Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives.Adenosine in inflammatory joint diseases.The Impact of Methylenetetrahydrofolate Reductase C677T Polymorphism on Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation with Methotrexate ProphylaxisMetabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.Pharmacogenetics of folate-related drug targets in cancer treatment.Molecular basis of antifolate resistance.Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis?The antifolatesLow-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate-resistant mice do not.
P2860
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P2860
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@en
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@nl
type
label
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@en
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@nl
prefLabel
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@en
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of 5-aminoimidazole ...... oxamide riboside and ribotide.
@en
P2093
B B Hudson
J E Baggott
W H Vaughn
P2860
P304
P356
10.1042/BJ2360193
P407
P577
1986-05-01T00:00:00Z