Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. - Wikidata - wikimedia - TriplyDB

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

http://www.wikidata.org/entity/Q42944792

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Akt and mTOR in B Cell Activation and Differentiation Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling Somatic mutagenesis in autoimmunity B lymphocyte antigen receptor signaling: initiation, amplification, and regulation Signaling by the phosphoinositide 3-kinase family in immune cells Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy.ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.Muscle-specific Pten deletion protects against insulin resistance and diabetes A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Cyclin D3 is selectively required for proliferative expansion of germinal center B cells.Gain-of-function mutations and immunodeficiency: at a loss for proper tuning of lymphocyte signaling.Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation PTEN: tumour suppressor, multifunctional growth regulator and more.Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.Hyperactivation and in situ recruitment of inflammatory Vδ2 T cells contributes to disease pathogenesis in systemic lupus erythematosus.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.The TCL1 family of oncoproteins: co-activators of transformation.A PTEN translational isoform has PTEN-like activity.

P2860

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P2860

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

http://www.wikidata.org/entity/Q42944792

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Critical roles of Pten in B ce ...... in class switch recombination.

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Critical roles of Pten in B ce ...... in class switch recombination.

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type

label

Critical roles of Pten in B ce ...... in class switch recombination.

@en

Critical roles of Pten in B ce ...... in class switch recombination.

@nl

prefLabel

Critical roles of Pten in B ce ...... in class switch recombination.

@en

Critical roles of Pten in B ce ...... in class switch recombination.

@nl

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P1433

Journal of Experimental Medicine

P1476

Critical roles of Pten in B ce ...... lin class switch recombination

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P2093

Akira Suzuki

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Manae Tsukio-Yamaguchi

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Minako Ohishi

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Tak Wah Mak

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Takeshi Tsubata

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Toru Nakano

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Tsuneyasu Kaisho

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P2860

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Cells in the marginal zone of the spleen

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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657-667

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10.1084/JEM.20021101

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P433

5

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197

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Pandelakis A. Koni

Takehiko Sasaki

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2003-03-01T00:00:00Z

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236241320

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12615906

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2193827

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