A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. - Wikidata - wikimedia - TriplyDB

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

http://www.wikidata.org/entity/Q43106462

about

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter Examination of the expanding pathways for the regulation of p21 expression and activity.The p53 circuit board Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S‑phase cell cycle arrest and apoptosis through caspase/cyclin‑CDK pathways.New insights into checkpoint kinase 1 in the DNA damage response signaling network.S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.CDK8: a positive regulator of transcription Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo.Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.p53-Dependent induction of PVT1 and miR-1204.The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling Transcriptional regulation by p53.Lysines in the tetramerization domain of p53 selectively modulate G1 arrest Bimodal regulation of p21(waf1) protein as function of DNA damage levels.A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.Differential regulation of p53 target genes: it's (core promoter) elementary.Cdk7: open questions beyond the prevailing model The C terminus of p53 binds the N-terminal domain of MDM2.A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition Fra-1 regulation of Matrix Metallopeptidase-1 (MMP-1) in metastatic variants of MDA-MB-231 breast cancer cells.CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

P2860

Q24302433-0AC0507B-414D-455D-8FCA-EC2DB12D0D07 Q24307618-CF21F29B-4D0E-48B2-8ED2-A976DAAC3DB9 Q27692024-649AE1D6-2BEF-46BB-896A-07EFE7991789 Q28259725-AAD072B7-1EFD-4BA5-B2AF-D65479B7CA62 Q33522347-0756DC6F-F94F-40F0-96E3-DEB5650C4AA2 Q34042861-4862E4D9-A0D9-42E8-A00D-06DA683BD59F Q34105233-A4B6803E-F531-4A38-820E-67E7AB644637 Q34129155-7636645B-A4E2-4177-9216-29EA52433F0F Q34313327-7F5CB971-1A35-47B7-8706-BF70515BEE28 Q34496093-E43CABBC-E4D2-44F7-A54A-FE9E55A6C7DA Q34558375-67CCC83A-77C3-4026-8B32-39F94DE72D3E Q35073758-D69116CB-4D2E-4544-9F59-D6CF6B7995F3 Q35273933-4BAE2072-CC24-4611-9981-13A00392A19A Q35709920-1B1039FF-4394-4B15-8A8D-7C591DE513A4 Q36116228-DC1B8D89-1765-4E11-9BF8-3FA5F4D3AC98 Q36282831-E79F2CE4-70C4-43BE-B091-7E5E9E417345 Q36659343-D62577B3-7CB1-4350-B56B-C53E778B0D0B Q36882319-1CA47A5F-7F5C-4CFA-A4B4-8C941AEC1A26 Q37474605-1197813C-F50F-4460-B6A4-009C82B4C1FD Q37725691-BB562C3A-2F5F-4E58-9AF4-00C1E4C24086 Q37777267-F70A8B35-CB27-44A0-B2F2-E671C2C66129 Q38769335-0853726D-E9F9-4328-A1D8-DBD2BDBD3368 Q38930942-448CD601-08E8-4B64-A82B-86D680F9A636 Q39150492-3FAA89A8-6D9F-4695-B99E-F44647C13328 Q39404029-6BE773A2-1E86-4407-86D9-616625FB4719 Q39645979-291C9D71-B2E4-4377-97BA-543FA764696D Q41846871-FFF6D361-5EDB-4CE1-BBF3-4841472329B4 Q41908813-CB30FC00-D7E7-4D32-A333-D6982AEBAE11 Q42044986-F66B3388-F590-44C0-9AFE-75E47FEA81A1 Q42410146-4D895D84-CFFA-438A-B5BB-93A2F63D096F Q42532759-5BDBDA04-FFFF-4288-B111-AA79AC6DCFFA Q42544809-0505FC97-3DA2-47CD-9CC7-A1CE2EAE0026 Q42940092-7118F1ED-ABC8-417B-80A7-FEF1F08DBA90 Q44529902-A87D6140-FDE4-4C44-8BE8-18E330512C17 Q50317222-34EAE996-13E0-4FE4-ADB8-200F266135E1

P2860

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

http://www.wikidata.org/entity/Q43106462

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@en

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@nl

type

label

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@en

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@nl

prefLabel

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@en

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@nl

P1433

Q43106462-329FBFCF-7185-445E-B2C6-A2A506DB327A

P1476

Q43106462-59E9A9CC-E7E5-4B8D-9B51-8D46AF898F1B

P2093

Q43106462-09C9F44A-025A-40A5-8F4A-281D26DA1AA1

Q43106462-389959D5-D682-4585-8233-2CB6DD3921EE

Q43106462-804D8098-6E61-421C-B76A-523A7E53E0F6

Q43106462-B68C512B-B457-43EB-8FB0-9D5F982FC567

Q43106462-C6BA5FA2-E586-45F7-9604-C43755383732

Q43106462-E24793B6-DDEE-4C73-AE3C-D57C0A1B582D

P2860

Q43106462-0124210B-2B23-441C-B0C5-88FE4A3D7F8B

Q43106462-03BE7103-8167-4AA2-9C3A-3B9908FD2D32

Q43106462-053C0D06-F8A3-4DB8-863B-AD0C6E5959D4

Q43106462-06CF8450-DB29-497E-8607-0B0FDAE49298

Q43106462-0E58E0E8-232D-4A76-8B69-8A60B9CD2EE4

Q43106462-108DE0D0-EFFF-475D-BD3A-7BD6F3AC40C2

Q43106462-1096059D-F2F8-42B3-90D3-C44196C7CA2D

Q43106462-1342B72B-4FC1-430F-BA67-E6782AEC6254

Q43106462-13840D04-B57C-487F-AA4B-F810CB35272D

Q43106462-1592646C-EDF3-426E-BA8E-155AEE9AC01B

P304

Q43106462-6F256E50-F64E-403D-A59F-1A270125EBF2

P31

Q43106462-937F3E8D-6AEE-45CB-920B-8B7AFCD3AB4D

P356

Q43106462-E8D5C0E4-0182-42C0-8584-2A00F29B9D78

P433

Q43106462-1413A110-F91C-4DF1-919F-33CF49289DA3

P478

Q43106462-36B27ADC-99C8-4FB3-83A0-A155319ECA73

P50

Q43106462-496B1FE9-CAC5-4451-A387-455F45DA5060

P577

Q43106462-B5B90171-B794-4867-A64F-D39DE8C13980

P5875

Q43106462-E8428D43-144D-48B7-9977-2B58B6D45775

P698

Q43106462-E4D33A1D-CB51-4F43-B5A3-5B02CF6AD4E8

P932

Q43106462-05B61603-A26D-499A-A3C6-E3053678F211

P356

P1433

Genes & Development

P1476

A role for Chk1 in blocking tr ...... during the S-phase checkpoint.

@en

P2093

Aaron J Donner

http://www.w3.org/2001/XMLSchema#string

Carol Prives

http://www.w3.org/2001/XMLSchema#string

Joaquin M Espinosa

http://www.w3.org/2001/XMLSchema#string

Melissa J Peart

http://www.w3.org/2001/XMLSchema#string

Melissa Mattia

http://www.w3.org/2001/XMLSchema#string

Rachel Beckerman

http://www.w3.org/2001/XMLSchema#string

P2860

Structure and function of the human transcription elongation factor DSIF

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

P304

1364-1377

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.1795709

http://www.w3.org/2001/XMLSchema#string

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

James L. Manley

P577

2009-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26258349

http://www.w3.org/2001/XMLSchema#string

P698

19487575

http://www.w3.org/2001/XMLSchema#string

P932

2701578

http://www.w3.org/2001/XMLSchema#string