2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).

Item
http://www.wikidata.org/entity/Q43170772
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell deathThe p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteinsTargeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?The complexities of p97 function in health and diseaseProteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cellsInhibitors of the AAA+ chaperone p97Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1.Synthesis of Substituted 2-Amino-1,3-oxazoles via Copper-Catalyzed Oxidative Cyclization of Enamines and N,N-Dialkyl Formamides.Drosophilaand Mouse Models of Hereditary Myopathy Caused by Mutations in VCP/p97
P2860

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).

Item
http://www.wikidata.org/entity/Q43170772
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@en
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@nl
type
label
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@en
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@nl
prefLabel
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@en
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2010.01.058
P407
P433
P478
P50
P577
P698