Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium.
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Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cellsA full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptorsIdentification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human β1-adrenoceptorAtenolol is inferior to metoprolol in improving left ventricular function and preventing ventricular remodeling in dogs with heart failure.Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacologyStress and cardiac beta adrenoceptors.Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricleUse of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells.A study of antagonist affinities for the human histamine H2 receptor.Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats.Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist.Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heartDetection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.Positive inotropic and lusitropic effects mediated via the low-affinity state of beta1-adrenoceptors in pithed rats.Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors.Atypical cardiostimulant beta-adrenoceptor in the rat heart: stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues.Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor.Effects of beta-adrenergic receptor blockers on cardiac function: a comparative study in male versus female rats.
P2860
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P2860
Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
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2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
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@zh-sg
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@yue
2002年學術文章
@zh-hant
name
Comparison of the affinity of ...... ferret ventricular myocardium.
@en
Comparison of the affinity of ...... ferret ventricular myocardium.
@nl
type
label
Comparison of the affinity of ...... ferret ventricular myocardium.
@en
Comparison of the affinity of ...... ferret ventricular myocardium.
@nl
prefLabel
Comparison of the affinity of ...... ferret ventricular myocardium.
@en
Comparison of the affinity of ...... ferret ventricular myocardium.
@nl
P2093
P2860
P356
P1476
Comparison of the affinity of ...... ferret ventricular myocardium.
@en
P2093
Alberto J Kaumann
Andrew A Grace
James A Lynham
Martin D Lowe
P2860
P304
P356
10.1038/SJ.BJP.0704450
P407
P577
2002-01-01T00:00:00Z