Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
about
Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genesCobalt(III)porphyrin to target G-quadruplex DNA.Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formationTargeting human telomerase for cancer therapeutics.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA."One Ring to Bind Them All"-Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Artificial human telomeres from DNA nanocircle templatesQuartet formation of a guanine derivative with an isopropyl group: crystal structures of "naked" G-quartets and thermodynamics of G-quartet formation.Telomere maintenance as a target for anticancer drug discovery.Pentose phosphate pathway function affects tolerance to the G-quadruplex binder TMPyP4Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNATelomeric G-quadruplexes are a substrate and site of localization for human telomeraseReevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of actionQuantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometryFour-stranded DNA: cancer, gene regulation and drug development.V-shaped dinuclear Pt(II) complexes: selective interaction with human telomeric G-quadruplex and significant inhibition towards telomeraseA hitchhiker's guide to G-quadruplex ligands.Interaction of metal complexes with G-quadruplex DNA.Fluorescent probes for G-quadruplex structures.G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.Template-assembled synthetic G-quadruplex (TASQ): a useful system for investigating the interactions of ligands with constrained quadruplex topologies.The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n.Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates.Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA.Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment.Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells.Putative DNA quadruplex formation within the human c-kit oncogene.Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA.Mass spectrometric studies on effects of counter ions of TMPyP4 on binding to human telomeric DNA and RNA G-quadruplexes.Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes.An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules.Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins.Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine.Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways.Effects of deficient of the Hoogsteen base-pairs on the G-quadruplex stabilization and binding mode of a cationic porphyrin.A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1.The Evidence of Cooperative Binding of a Ligand to G4 DNA.
P2860
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P2860
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Quadruplex-interactive agents ...... the inhibition of telomerase.
@en
Quadruplex-interactive agents ...... the inhibition of telomerase.
@nl
type
label
Quadruplex-interactive agents ...... the inhibition of telomerase.
@en
Quadruplex-interactive agents ...... the inhibition of telomerase.
@nl
prefLabel
Quadruplex-interactive agents ...... the inhibition of telomerase.
@en
Quadruplex-interactive agents ...... the inhibition of telomerase.
@nl
P2093
P356
P1476
Quadruplex-interactive agents ...... the inhibition of telomerase.
@en
P2093
P304
P356
10.1021/JM010246U
P407
P577
2001-12-01T00:00:00Z