Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
about
Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cellsBLM helicase facilitates telomere replication during leading strand synthesis of telomeresMany disease-associated variants of hTERT retain high telomerase enzymatic activityControlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame.A Nitroxide-Tagged Platinum(II) Complex Enables the Identification of a DNA G-Quadruplex Binding ModeA novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cellsFluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligandsStructural insights into G-quadruplexes: towards new anticancer drugs.Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines.Assays for human telomerase activity: progress and prospects.Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugatesA G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.G-quadruplexes in viruses: function and potential therapeutic applications.A Discovery Funnel for Nucleic Acid Binding Drug CandidatesInsights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.G-quadruplexes: from guanine gels to chemotherapeuticsInduction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityFANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stabilityPyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cellsInteractions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds.DNA secondary structures: stability and function of G-quadruplex structures.A hitchhiker's guide to G-quadruplex ligands.Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cellsApplications of isothermal titration calorimetry in biophysical studies of G-quadruplexes.Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.Methods for investigating G-quadruplex DNA/ligand interactions.Targeting non-B-form DNA in living cells.G-quadruplexes as potential therapeutic targets for embryonal tumors.Helicases, G4-DNAs, and drug design.Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs.Evaluation of alkaloids binding to the parallel quadruplex structure [d(TGGGGT)]4 by electrospray ionization mass spectrometry.Complexes of the antitumoral drugs Doxorubicin and Sabarubicin with telomeric G-quadruplex in basket conformation: ground and excited state properties.Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures.
P2860
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P2860
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Reevaluation of telomerase inh ...... and their mechanisms of action
@ast
Reevaluation of telomerase inh ...... and their mechanisms of action
@en
type
label
Reevaluation of telomerase inh ...... and their mechanisms of action
@ast
Reevaluation of telomerase inh ...... and their mechanisms of action
@en
prefLabel
Reevaluation of telomerase inh ...... and their mechanisms of action
@ast
Reevaluation of telomerase inh ...... and their mechanisms of action
@en
P2860
P50
P356
P1476
Reevaluation of telomerase inh ...... and their mechanisms of action
@en
P2093
Elsa De Lemos
Patrick Reichenbach
P2860
P304
17347-17352
P356
10.1073/PNAS.0707365104
P407
P50
P577
2007-10-22T00:00:00Z