Epac: a new cAMP target and new avenues in cAMP research.
about
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.Regulation of renal urea transport by vasopressinAKAP18 contains a phosphoesterase domain that binds AMPSelective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMPExchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neuronsInhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta productionRole of EPAC in cAMP-Mediated Actions in Adrenocortical CellsE-type prostanoid receptor 4 (EP4) in disease and therapyAssembly of allosteric macromolecular switches: lessons from PKAAlterations of cAMP-dependent signaling in dystrophic skeletal muscleRole of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiologyGlucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Cell physiology of cAMP sensor Epac.Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cellsPituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiationDynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexesModeling cell signaling networksMitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cellsThe contribution of AKAP5 in amylase secretion from mouse parotid aciniAKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascadeAVP-induced increase in AQP2 and p-AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidneyEpac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migrationProstaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase AStimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunitNerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to EpacAdrenaline increases glucose transport via a Rap1-p38MAPK pathway in rat vascular smooth muscle cellsSrc-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiationPhosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson diseaseRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Decreased expression of A-kinase anchoring protein 150 in GT1 neurons decreases neuron excitability and frequency of intrinsic gonadotropin-releasing hormone pulses.Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells.Epac2-mediated dendritic spine remodeling: implications for disease.PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.Quantitative measurement of cAMP concentration using an exchange protein directly activated by a cAMP-based FRET-sensor.Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.cAMP potentiates InsP3-induced Ca2+ release from the endoplasmic reticulum in blowfly salivary glands.Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
P2860
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P2860
Epac: a new cAMP target and new avenues in cAMP research.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Epac: a new cAMP target and new avenues in cAMP research.
@en
Epac: a new cAMP target and new avenues in cAMP research.
@nl
type
label
Epac: a new cAMP target and new avenues in cAMP research.
@en
Epac: a new cAMP target and new avenues in cAMP research.
@nl
prefLabel
Epac: a new cAMP target and new avenues in cAMP research.
@en
Epac: a new cAMP target and new avenues in cAMP research.
@nl
P356
P1476
Epac: a new cAMP target and new avenues in cAMP research.
@en
P2093
Johannes L Bos
P2888
P304
P356
10.1038/NRM1197
P577
2003-09-01T00:00:00Z
P5875
P6179
1003217194