Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. - Wikidata - wikimedia - TriplyDB

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.

http://www.wikidata.org/entity/Q43862866

about

Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair Looking beneath the surface to determine what makes DNA damage deleterious Base excision repair and cancer DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair Repair of DNA-polypeptide crosslinks by human excision nuclease.Irreversible inhibition of DNA polymerase beta by an oxidized abasic lesion.FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells.Reactivity of Nucleic Acid Radicals.The biological and metabolic fates of endogenous DNA damage products The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.Inhibition of short patch and long patch base excision repair by an oxidized abasic site.Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage.RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria.Long patch base excision repair compensates for DNA polymerase β inactivation by the C4'-oxidized abasic site.Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.Rapid determination of the active fraction of DNA repair glycosylases: a novel fluorescence assay for trapped intermediates.Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone.Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates.DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair.Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA.The mutagenicity of thymidine glycol in Escherichia coli is increased when it is part of a tandem lesion Abasic and oxidized abasic site reactivity in DNA: enzyme inhibition, cross-linking, and nucleosome catalyzed reactions.Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Epimeric 2-deoxyribose lesions: Products from the improper chemical repair of 2-deoxyribose radicals.Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions.Mechanisms of DNA-protein crosslink repair.Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones.Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal.2'-deoxyribonolactone lesion produces G->A transitions in Escherichia coli.GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin.Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments.DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides.DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage.Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1.Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta.Formation and repair of DNA-protein crosslink damage.

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P2860

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.

http://www.wikidata.org/entity/Q43862866

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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name

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@en

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@nl

type

label

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@en

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@nl

prefLabel

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@en

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Covalent trapping of human DNA ...... A lesion 2-deoxyribonolactone.

@en

P2093

Brian C Bales

http://www.w3.org/2001/XMLSchema#string

Bruce Demple

http://www.w3.org/2001/XMLSchema#string

Donny Wong

http://www.w3.org/2001/XMLSchema#string

Ergin Beyret

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Jae-Taeg Hwang

http://www.w3.org/2001/XMLSchema#string

Marc M Greenberg

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Michael S DeMott

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P2860

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product

5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro.

Regulation of eukaryotic abasic endonucleases and their role in genetic stability

Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage.

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry.

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7637-7640

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10.1074/JBC.C100577200

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10

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P478

277

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2002-01-22T00:00:00Z

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11805079

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