Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
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GSK-3: tricks of the trade for a multi-tasking kinaseThe dynamic nature of the kinomeTFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic strokeBinding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsp42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Chemical biology in stem cell research.A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.Using small molecules to study big questions in cellular microbiology.An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cellsIdentification of a secreted casein kinase 1 in Leishmania donovani: effect of protein over expression on parasite growth and virulence.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease ModelsThe role of targeted chemical proteomics in pharmacology.Kinase selectivity profiling by inhibitor affinity chromatography.Second-generation kinase inhibitors.A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.Deregulated Cdk5 activity is involved in inducing Alzheimer's diseaseMetal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation.A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry.Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stageComputational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.Mutual action of anticancer and antiparasitic drugs: are there any shared targets?Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.Metabolism of two new benzodiazepine-type anti-leishmanial agents in rat hepatocytes and hepatic microsomes and their interaction with glutathione in macrophages.Exploring the specificity of the PI3K family inhibitor LY294002.Structure-aided optimization of kinase inhibitors derived from alsterpaullone.Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors.Ruthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c]quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity.Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands
P2860
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P2860
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@en
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@nl
type
label
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@en
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@nl
prefLabel
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@en
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@nl
P2093
P2860
P356
P1476
Intracellular Targets of Paull ...... tion on immobilized inhibitor.
@en
P2093
Conrad Kunick
Karen Wieking
Laurent Meijer
Marie Knockaert
Maryse Leost
Sophie Schmitt
P2860
P304
25493-25501
P356
10.1074/JBC.M202651200
P407
P577
2002-04-18T00:00:00Z