Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
about
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1aThe tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinityInteraction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependentAcid-sensing ion channels in pain and disease.Structure and activity of the acid-sensing ion channelsTwo aspects of ASIC function: Synaptic plasticity and neuronal injury.Selective regulation of acid-sensing ion channel 1 by serine proteasesASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filtersA single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1aProtons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cellsFunctional modifications of acid-sensing ion channels by ligand-gated chloride channels.Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulationAcid-sensing ion channels: trafficking and synaptic function.Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant.ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domainZebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+.Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosisHeteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal deathENaCs and ASICs as therapeutic targets.Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition.Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism.A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gatingASIC subunit ratio and differential surface trafficking in the brain.Two novel DEG/ENaC channel subunits expressed in glia are needed for nose-touch sensitivity in Caenorhabditis elegans.The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction.Extracellular calcium as an integrator of tissue function.Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channelProtonation controls ASIC1a activity via coordinated movements in multiple domains.Identification of protein domains that control proton and calcium sensitivity of ASIC1a.Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.Insight into DEG/ENaC channel gating from genetics and structure.
P2860
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P2860
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Alternative splicing and inter ...... sensing ion channel 1 (ASIC1).
@en
Alternative splicing and inter ...... of acid-sensing ion channel 1
@nl
type
label
Alternative splicing and inter ...... sensing ion channel 1 (ASIC1).
@en
Alternative splicing and inter ...... of acid-sensing ion channel 1
@nl
prefLabel
Alternative splicing and inter ...... sensing ion channel 1 (ASIC1).
@en
Alternative splicing and inter ...... of acid-sensing ion channel 1
@nl
P2093
P2860
P356
P1476
Alternative splicing and inter ...... sensing ion channel 1 (ASIC1).
@en
P2093
Elena Babini
Hyun-Soon Geisler
Martin Paukert
P2860
P304
41597-41603
P356
10.1074/JBC.M205877200
P407
P577
2002-08-26T00:00:00Z