about
The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxiaHuman AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNAOxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOStructural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediatesThe oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesStructure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylationMechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylaseInhibition of 2-oxoglutarate dependent oxygenasesAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemRepair of methylation damage in DNA and RNA by mammalian AlkB homologuesA miniaturized screen for inhibitors of Jumonji histone demethylases.Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.Targeting histone lysine demethylases - progress, challenges, and the futureKinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation.Direct reversal of DNA alkylation damage.Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteinsInverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.Viral AlkB proteins repair RNA damage by oxidative demethylationRhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA DamageQuantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymesNucleic acid oxidation in DNA damage repair and epigeneticsOxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase.Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein.Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins.Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species.Fe(II)/alpha-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism.Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans.Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases.Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands.Investigations on the role of a solvent tunnel in the α-ketoglutarate dependent oxygenase factor inhibiting HIF (FIH).Homology modeling and function prediction of hABH1, involving in repair of alkylation damaged DNA.Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The selectivity and inhibition of AlkB.
@en
The selectivity and inhibition of AlkB.
@nl
type
label
The selectivity and inhibition of AlkB.
@en
The selectivity and inhibition of AlkB.
@nl
prefLabel
The selectivity and inhibition of AlkB.
@en
The selectivity and inhibition of AlkB.
@nl
P2093
P2860
P356
P1476
The selectivity and inhibition of AlkB.
@en
P2093
Imre Schlemminger
Kirsty S Hewitson
Luke A McNeill
Richard W D Welford
P2860
P304
10157-10161
P356
10.1074/JBC.M211058200
P407
P577
2003-01-06T00:00:00Z