Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.
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Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesAdhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activityFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsCross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation siteCTLs respond with activation and granule secretion when serving as targets for T-cell recognitionAssociation of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transductionT cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cellsDifferential modulation of CD8beta by rat gammadelta and alphabeta T cells after activationActivated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influxA dominant-negative transgene defines a role for p56lck in thymopoiesis.Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptorInnate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4.Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor moleculesp56lck interacts via its src homology 2 domain with the ZAP-70 kinase.Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell.CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity.The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionCD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase.Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.The lymphocyte-specific tyrosine protein kinase p56lck.The c-src family of protein-tyrosine kinases.CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturationTargeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.CD8 controls T cell cross-reactivity.Coreceptors and adapter proteins in T-cell signaling.
P2860
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P2860
Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh-hant
name
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@en
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@nl
type
label
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@en
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@nl
prefLabel
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@en
Inability of CD8 alpha' polype ...... nd lack of expression in vivo.
@nl
P2093
P356
P1433
P1476
Inability of CD8 alpha' polype ...... and lack of expression in vivo
@en
P2093
P2888
P304
P356
10.1038/342278A0
P407
P577
1989-11-01T00:00:00Z
P6179
1011008614