Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
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Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survivalChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsCyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levelsCalcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosisRegulation of the insulin gene by glucose and fatty acidsRole of ceramide in diabetes mellitus: evidence and mechanisms.Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.An islet in distress: β cell failure in type 2 diabetes.Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolismGlucolipotoxicity of the pancreatic beta cell.Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families.Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicityNovel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosisGene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg DebateSphingolipids in obesity, type 2 diabetes, and metabolic disease.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretionAdiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regenerationFree fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways.ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cellsFoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytesElimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damageGPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.Ceramides as modulators of cellular and whole-body metabolismRoles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.Sphingolipids in cardiovascular diseases and metabolic disordersChronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-CellsSphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.A simple matter of life and death-the trials of postnatal Beta-cell mass regulation
P2860
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P2860
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@en
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@nl
type
label
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@en
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@nl
prefLabel
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@en
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@nl
P2093
P2860
P356
P1476
Palmitate inhibition of insuli ...... level via ceramide synthesis.
@en
P2093
Barton Wicksteed
Christopher J Rhodes
Cynthia L Kelpe
Patrick C Moore
Susan D Parazzoli
P2860
P304
30015-30021
P356
10.1074/JBC.M302548200
P407
P577
2003-05-27T00:00:00Z