Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
about
Atypical protein kinase C in cardiometabolic abnormalitiesInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverInsulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesisInsulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiationRole of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistanceInhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolismAdenovirus infection results in alterations of insulin signaling and glucose homeostasis.Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthOleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C.Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart FailureOverexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.RNA-sequencing analysis of 5' capped RNAs identifies many new differentially expressed genes in acute hepatitis C virus infectionProtein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese miceBMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humansRole of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytesInsulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways.Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum.Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.A short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity.Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ιThe Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial.Tissue specificity on insulin action and resistance: past to recent mechanisms.IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.Tissue-specificity of insulin action and resistance.The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling.Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice.Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.Sasa veitchii extract reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage.Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.
P2860
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P2860
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@en
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@nl
type
label
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@en
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@nl
prefLabel
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@en
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@nl
P2093
P1433
P1476
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
@en
P2093
Angela M Valverde
Deborah J Burks
José Carretero
Morris F White
Tracey L Fisher
P304
P356
10.2337/DIABETES.52.9.2239
P407
P577
2003-09-01T00:00:00Z