Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process
about
Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanismTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoMolecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosisMolecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotidesChromosomal translocations involving the MLL gene: molecular mechanisms.Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspotMolecular pathogenesis of secondary acute promyelocytic leukemiaCauses of oncogenic chromosomal translocation.Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndromeRearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.Etoposide-initiated MLL rearrangements detected at high frequency in human primitive hematopoietic stem cells with in vitro and in vivo long-term repopulating potential.Topoisomerase II and leukemia.Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcriptionGenome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity.From initiation to eradication: the lifespan of an MLL-rearranged therapy-related paediatric AML.Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia
P2860
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P2860
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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name
Reciprocal DNA topoisomerase I ...... rhangs that anneal to form der
@nl
Reciprocal DNA topoisomerase I ...... ed AML without further process
@en
type
label
Reciprocal DNA topoisomerase I ...... rhangs that anneal to form der
@nl
Reciprocal DNA topoisomerase I ...... ed AML without further process
@en
prefLabel
Reciprocal DNA topoisomerase I ...... rhangs that anneal to form der
@nl
Reciprocal DNA topoisomerase I ...... ed AML without further process
@en
P2093
P2860
P356
P1433
P1476
Reciprocal DNA topoisomerase I ...... ed AML without further process
@en
P2093
Carolyn A Felix
Charles Saginario
Diana J Slater
Eric F Rappaport
Eva Hilgenfeld
Ian A Blair
Martin Carroll
Maureen D Megonigal
Mingli Liu
Nai-Kong V Cheung
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207052
P407
P577
2003-11-01T00:00:00Z