Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.
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Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase IInhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityImmunodetection of human topoisomerase I-DNA covalent complexes8-Oxoguanine rearranges the active site of human topoisomerase IStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexProcessing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesteraseConversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff.Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Leukemias related to treatment with DNA topoisomerase II inhibitors.Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity.Structural basis for topoisomerase I inhibition by nucleoside analogs.Mechanisms of apoptosis induction by nucleoside analogs.Repair of topoisomerase I-mediated DNA damage.Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA.Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair.TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread.p53 stimulates human topoisomerase I activity by modulating its DNA binding.Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides.Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processRad9 protects cells from topoisomerase poison-induced cell death.Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro
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Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Induction of topoisomerase I c ...... ro and in ara-C-treated cells.
@en
Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine
@nl
type
label
Induction of topoisomerase I c ...... ro and in ara-C-treated cells.
@en
Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine
@nl
prefLabel
Induction of topoisomerase I c ...... ro and in ara-C-treated cells.
@en
Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine
@nl
P2093
P2860
P356
P1476
Induction of topoisomerase I c ...... ro and in ara-C-treated cells.
@en
P2093
Kohlhagen G
Pourquier P
Takebayashi Y
P2860
P304
P356
10.1073/PNAS.97.4.1885
P407
P577
2000-02-01T00:00:00Z